Go to Choice City and Tap & Handle...skip the Mayor (no one down here likes them peeps).
But you're right, there's a lot of breweries to hit up there and most of them are close together.
Been to all 3 of those places.
I liked the Mayor of Old Town for their beer list, but do think they would benefit a lot if they started to employ more beer fans/geeks as their servers rather than the generic college student who has no interest in studying up on the beer they serve.
Both Choice City and Tap N Handle have great taps and I like the atmosphere of being those places far better, but the tap list at Mayor is at least 5x the size of the others and just as quality in their choices, no filler. I mentioned this here already but I went during the day as well as it being in the summer when CSU isn't in session, thus it was dead, so I don't think I had the typical experience and I could definitely see how that place could start to suck when schools in session and that place gets crowded. My experience was positive though.
And at least they have a TV playing sports in the background. I definitely enjoyed Tap N Handle for a bar a lot more for the vibe but them not having a TV is a bit of a roadblock for me. I am not opposed to hitting bars up solo, especially now that I live in a city where the only person I know is my roommate, but I kinda need the security of a TV to do so. That way, if I don't find someone sitting next to me to talk with I can turn my attention to some sports while I enjoy some beers. ( know the taprooms don't have TV's either but I have also only gotten flights there, as well as growler fills, and then bolted.) I definitely preferred Tap N Handle to Mayor, and every time I have been in town with someone and hit up a bar that has been the choice spot (after a meal at CC), but there are times when I can see choosing the Mayor.